CPFT recruiting for largest UK study of mid-life risk factors for dementia

CPFT is recruiting people to take part in the largest UK study to identify factors in middle age that put a person at the greatest risk of developing dementia.

CPFT recruiting for largest UK study of mid-life risk factors for dementia
11 April 2017

CPFT is now recruiting people in Cambridgeshire to get involved in a study funded by Alzheimer’s Society. The PREVENT study aims to identify biological markers of dementia and changes in risk factors in people many years before they would be expected to develop dementia symptoms.

Previous studies have focused on the older population, however recent research suggests that the changes that occur in the brain and blood may well precede the symptoms of Alzheimer’s disease by many years if not decades. This suggests that a very early disease process has started well before people develop the typical symptoms of dementia such as memory loss. If this is the case then doctors may be able to identify disease at a very early stage and prevent or delay the disease from developing into dementia.

The PREVENT study aims to recruit 700 people aged 40 to 59 years who currently show no signs or symptoms of dementia. Following the successful recruitment of 250 people in London and Edinburgh, the study has expanded to include Cambridge and Oxford. CPFT is running the study in Cambridgeshire.

Professor John O’Brien, Community Division Academic Lead at CPFT and PREVENT lead at the University of Cambridge, said: “We are delighted to open the Cambridge PREVENT centre, to expand this important study on investigating risk factors and early biomarker changes in those at risk of future dementia. Such studies are essential if we are to move in a meaningful way towards studies of reducing risk and, ultimately, preventing dementia.”

PREVENT is looking for the smallest and earliest biological differences between people at high risk of dementia and those at low risk. Changes in everything from memory and brain scans to blood and saliva will be measured, taking into account a person’s lifestyle, genetics, diet, physical and mental health.

After an initial visit and tests, and a follow-up after two years, researchers are hoping to then monitor participants every five years. Early results from PREVENT have shown that people with a high risk of dementia have different patterns of brain activity when they are unable to recall pictures compared to people at low risk.

People aged 40 to 59 can register their interest in joining the study at: preventdementia.co.uk

 

For more information about the ground-breaking research CPFT is involved in click here

Cambridgeshire and Peterborough NHS Foundation Trust
Elizabeth House, Fulbourn Hospital
Cambridge, CB21 5EF

T 01223 219400 (open 8:30am to 5pm)
F 01480 398501

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