‘Game Show’ app found to improve memory in people in early stages of dementia

A ‘brain training’ game app developed by researchers at Cambridgeshire and Peterborough NHS Foundation Trust (CPFT) and the University of Cambridge could help improve the memory of patients with memory difficulties, who might be in the very earliest stages of dementia.

‘Game Show’ app found to improve memory in people in early stages of dementia
03 July 2017

‘Game Show’ app found to improve memory of people in early stages of dementia

The results of the study, published today, showed that patients who played the game made around a third fewer errors, needed fewer trials and improved their memory score by around 40%, and had correctly remembered the locations of more information at the first attempt on a test of episodic memory.

Episodic memory is important for day-to-day activities and is used, for example, when remembering where we left our keys in the house or where we parked our car in a multi-story car park. Compared to the control group, the cognitive training group also retained more complex visual information after training.

Day-to-day memory difficulties and problems of motivation or amnestic mild cognitive impairment (aMCI) - has been described as the transitional stage between ‘healthy ageing’ and dementia. It is characterised. At present, there are no approved drug treatments for the cognitive impairments of patients affected by the condition.

Cognitive training has shown some benefits, such as speed of attentional processing, for patients with aMCI, but training packages are typically repetitive and boring, affecting patients’ motivation. To overcome this problem, researchers from the CPFT and the Departments of Psychiatry and Clinical Neurosciences and the Behavioural and Clinical Neuroscience Institute at the University of Cambridge developed ‘Game Show’, a memory game app, in collaboration with patients with aMCI, and tested its effects on cognition and motivation.

Professor Barbara Sahakian, co-inventor of the game and consultant psychologist at CPFT, said: “Good brain health is as important as good physical health. There's increasing evidence that brain training can be beneficial for boosting cognition and brain health, but it needs to be based on sound research and developed with patients. It also needs to be enjoyable enough to motivate users to keep to their programmes. Our game allowed us to individualise a patient’s cognitive training programme and make it fun and enjoyable for them to use.”

The researchers randomly assigned forty-two patients, some from CPFT, with amnestic MCI to either the cognitive training or control group. Participants in the cognitive training group played the memory game for a total of eight one-hour sessions over a four-week period. Participants in the control group continued their clinic visits as usual.

In the game, which participants played on an iPad, the player takes part in a game show to win gold coins. In each round, they are challenged to associate different geometric patterns with different locations. Each correct answer allows the player to earn more coins. Rounds continue until completion or after six incorrect attempts are made. The better the player gets, the higher the number of geometric patterns presented – this helps tailor the difficulty of the game to the individual’s performance to keep them motivated and engaged. A game show host encourages the player to maintain and progress beyond their last played level.

The results, published today in The International Journal of Neuropsychopharmacology, showed that patients had correctly remembered the locations of more information at the first attempt on a test of episodic memory.

In addition, participants in the cognitive training group indicated that they enjoyed playing the game and were motivated to continue playing across the eight hours of cognitive training. Their confidence and subjective memory also increased with gameplay. The researchers say that this demonstrates that games can help maximise engagement with cognitive training.

Dr George Savulich, the lead scientist on the study, adds: “Patients found the game interesting and engaging and felt motivated to keep training throughout the eight hours. We hope to extend these findings in future studies of healthy ageing and mild Alzheimer’s disease.”

The researchers hope to follow this published study up with a future large-scale study and to determine how long the cognitive improvements persist.

The research was only made possible because of the valuable contribution of patients, recruited from CPFT, Cambridge University Hospitals and Norfolk and Suffolk NHS Foundation Trusts.  

Notes to editors

The design of ‘Game Show’ was based on published research from the Sahakian Laboratory at the University of Cambridge. The study was funded by Janssen Pharmaceuticals/J&J and Wellcome.

In 2015, Professor Sahakian and colleagues showed that another iPad game developed by her team was effective at improving the memory of patients with schizophrenia, helping them in their daily lives at work and living independently. The Wizard memory game is available through PEAK via the App Store and Google Play.

Reference: George Savulich, Thomas Piercy, Chris Fox, John Suckling, James Rowe, John O'Brien, Barbara Sahakian. Cognitive training using a novel memory game on an iPad in patients with amnestic mild cognitive impairment (aMCI). The International Journal of Neuropsychopharmacology; 3 July 2017

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