Cambridge Psychosis Centre

Cambridge Psychosis Centre

Our multidisciplinary team of experts provides specialist advice and guidance for the pharmacological management and treatment of schizophrenia. We are a research active service and offer opportunities for people to test cutting-edge novel therapies and treatments, translating the latest discoveries into psychosis care. We can also provide assistance with new medicines and non-formulary prescriptions.

People diagnosed with schizophrenia experience a wide range of symptoms which include delusions and hallucinations but also negative symptoms such as lack of motivation and memory problems, as well as anxiety, depression, movement disorders and physical health problems. 
The pharmacological treatment of schizophrenia symptoms can be very complex and not all patients respond well to antipsychotics, which can cause significant side effects.

Our specialist service works at the forefront of psychosis research to support the most complex cases which may be resistant to standard treatments. We work with patients to find new routes to recovery, considering all available evidence-based options.

How our service can help

The Cambridge Psychosis Centre offers expert multidisciplinary assessment and guidance for three main phases of the pharmacological treatment of schizophrenia:

  • Managing persistent psychotic symptoms
  • Treating non-psychotic symptoms
  • Minimising side effects

Our full psychiatric assessment includes:

  • Personal and family history that might impact symptoms, including trauma and neurodevelopmental comorbidities as autism spectrum disorder (ASD) or Asperger’s.
  • Medication history including compliance, criteria for drug-resistance and augmentation strategies.
  • Comprehensive assessment of non-psychotic symptoms with specific tools: lack of motivation, emotional blunting, memory and attention problems, mood disorders, obsessive-compulsive and anxiety symptoms.
  • Evaluation of side effects: movement disorder, metabolic complications, sedation, constipation and hypersalivation.

Following assessment, the team will review the case and produce a full referenced report with treatment recommendations. We will provide assistance for non-formulary treatment and referrals to the clozapine community initiation committee. For selected cases, with prior agreement we will support use of botulin toxin for hypersalivation.

Referral information

We accept internal and external referrals for clinical assessment and pharmacological recommendations. There are two main routes:

Local/internal referrals for patients in Cambridgeshire and Peterborough mental health services

Please email a referral to including patient number, medication (current and past) and the main reason for referral. 

External referrals for patients in other mental health services

Please email
Prior funding approval will be needed from the relevant Clinical Commissioning Group (CCG) for a full formal assessment or botulin toxin treatment.

Research projects

Anyone wishing to take part in psychosis or schizophrenia research studies or to collaborate on research projects can contact Emilio at to find out about suitable opportunities. Potential volunteers can also be referred by clinical care teams, internally at CPFT via

Current research projects

The Cambridge Psychosis Centre runs an active research portfolio of ethically approved studies. Potential volunteers can be referred by their care teams but can also contact the research team directly via

Pharmacological trials

There are a few studies with CPFT progressing through different research approval stages. Please contact to find out more.

Non-pharmacological studies

Poor motivation is a key problem for people with schizophrenia. We aim to understand the brain mechanism causing this and other negative symptoms. Read the information sheet for more details.

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Professor Ed Bullmore, Honorary Consultant Psychiatrist

Professor Ed Bullmore, Honorary Consultant Psychiatrist

Ed Bullmore MB PhD FRCP FRCPsych FMedSci trained in medicine at the University of Oxford and St Bartholomew’s Hospital, London; then in psychiatry at the Bethlem Royal and Maudsley Hospital, London.
He joined the University of Cambridge as Professor of Psychiatry in 1999 and was Head of the Department of Psychiatry from 2014-2021. He is currently Director of the Wolfson Brain Imaging Centre, and Deputy Head of the School of Clinical Medicine. He is also an Honorary Consultant Psychiatrist and Director of Research and Development at CPFT.
Ed's research focuses on immuno-psychiatry, detailed in his best-selling book “The Inflamed Mind” (2018).
He has published more than 500 scientific papers and has been highly cited (Google h-index 173). He has been elected a Fellow of the Royal College of Physicians, the Royal College of Psychiatrists, and the Academy of Medical Sciences (AMS) and served as Treasurer of the AMS since 2018.

As a patient

As a patient, relative or carer using our services, sometimes you may need to turn to someone for help, advice, and support. 

Patient Advice and Liaison service  Contact the Trust